/* ==========================================================================
   Medicine detail — pharma radial infographic design
   Exact-value reproduction: colors, spacing, radii, weights, positioning.
   Self-contained design system (RTL, own dark-mode class strategy).
   ========================================================================== */

:root {
    --pharma-teal: #2C6478;
    --pharma-teal-dark: #1B3F4C;
    --pharma-emerald: #9C9569;
    --pharma-amber: #D9D2A5;
    --pharma-amber-dark: #A79F6C;
    --pharma-ink: #0F172A;
    --pharma-mist: #F4EBE1;
    --pharma-blue: #A7BCC5;

    /* Tailwind slate scale */
    --slate-50: #f8fafc;
    --slate-100: #f1f5f9;
    --slate-200: #e2e8f0;
    --slate-400: #94a3b8;
    --slate-500: #64748b;
    --slate-600: #475569;
    --slate-700: #334155;
    --slate-800: #1e293b;
    --slate-900: #0f172a;
    --slate-950: #020617;

    --shadow-sm: 0 1px 2px 0 rgb(0 0 0 / 0.05);
    --shadow-2xl: 0 25px 50px -12px rgb(0 0 0 / 0.25);
}

html, body {
    overflow-x: hidden;
}

.pharma-scope {
    font-family: "Droid Arabic Kufi", "Noto Kufi Arabic", "Figtree", ui-sans-serif, system-ui, -apple-system, "Segoe UI", Roboto, Helvetica, Arial, sans-serif;
    color: var(--slate-800);
    background: #fff;
    overflow-x: hidden;
}

.pharma-scope * {
    box-sizing: border-box;
}

.pharma-scope img {
    max-width: 100%;
    display: block;
}

.pharma-scope svg {
    display: block;
}

html.dark .pharma-scope,
[data-theme="dark"] .pharma-scope {
    background: var(--pharma-ink);
    color: var(--slate-100);
}

/* ---------------- Page shell ---------------- */
.pharma-shell {
    max-width: 56rem;
    margin: 0 auto;
    padding: 2.5rem 1rem;
}

@media (min-width: 640px) {
    .pharma-shell {
        padding-left: 1.5rem;
        padding-right: 1.5rem;
    }
}

/* ---------------- Back link ---------------- */
.pharma-back {
    display: inline-flex;
    align-items: center;
    gap: 0.375rem;
    font-size: 0.875rem;
    color: var(--slate-500);
    text-decoration: none;
    margin-bottom: 1.5rem;
    transition: color 0.2s ease-in-out;
}

html.dark .pharma-back,
[data-theme="dark"] .pharma-back {
    color: var(--slate-400);
}

.pharma-back:hover {
    color: var(--pharma-teal);
}

.pharma-back svg {
    width: 16px;
    height: 16px;
}

[dir="rtl"] .pharma-back svg {
    transform: rotate(180deg);
}

/* ---------------- Header row ---------------- */
.pharma-header {
    display: flex;
    flex-wrap: wrap;
    align-items: flex-start;
    gap: 0.75rem;
    margin-bottom: 2rem;
}

.pharma-header-img {
    height: 56px;
    width: 56px;
    object-fit: cover;
    border-radius: 1rem;
    border: 1px solid var(--slate-100);
    box-shadow: var(--shadow-sm);
    flex-shrink: 0;
}

html.dark .pharma-header-img,
[data-theme="dark"] .pharma-header-img {
    border-color: var(--slate-700);
}

.pharma-title-block h1 {
    font-size: 1.5rem;
    line-height: 2rem;
    font-weight: 800;
    color: var(--slate-800);
    margin: 0;
}

html.dark .pharma-title-block h1,
[data-theme="dark"] .pharma-title-block h1 {
    color: #fff;
}

@media (min-width: 640px) {
    .pharma-title-block h1 {
        font-size: 1.875rem;
        line-height: 2.25rem;
    }
}

.pharma-category-pill {
    display: inline-flex;
    align-items: center;
    border-radius: 9999px;
    background: var(--pharma-mist);
    padding: 0.125rem 0.625rem;
    font-size: 0.75rem;
    line-height: 1rem;
    font-weight: 600;
    color: var(--pharma-teal-dark);
    margin-top: 0.25rem;
}

html.dark .pharma-category-pill,
[data-theme="dark"] .pharma-category-pill {
    background: var(--slate-800);
    color: var(--pharma-teal);
}

.pharma-stats {
    display: inline-flex;
    align-items: center;
    gap: 0.75rem;
    margin-top: 0.5rem;
    font-size: 0.75rem;
    color: var(--slate-500);
}

html.dark .pharma-stats,
[data-theme="dark"] .pharma-stats {
    color: var(--slate-400);
}

.pharma-stats span {
    display: inline-flex;
    align-items: center;
    gap: 0.25rem;
}

.pharma-stats svg {
    width: 14px;
    height: 14px;
}

.pharma-actions {
    display: flex;
    gap: 0.5rem;
    margin-inline-start: auto;
}

.pharma-pill-btn {
    display: inline-flex;
    align-items: center;
    gap: 0.375rem;
    border-radius: 9999px;
    padding: 0.625rem 1.25rem;
    font-size: 0.875rem;
    line-height: 1.25rem;
    font-weight: 600;
    box-shadow: var(--shadow-sm);
    text-decoration: none;
    border: none;
    cursor: pointer;
    transition: opacity 0.2s ease-in-out, background-color 0.2s ease-in-out;
    white-space: nowrap;
}

.pharma-pill-btn svg {
    width: 16px;
    height: 16px;
}

.pharma-pill-btn--solid {
    background: linear-gradient(to right, var(--pharma-teal), var(--pharma-emerald));
    color: #fff;
}

.pharma-pill-btn--solid:hover {
    opacity: 0.9;
}

.pharma-pill-btn--outline {
    background: transparent;
    color: var(--pharma-teal);
    border: 1px solid var(--pharma-teal);
}

.pharma-pill-btn--outline:hover {
    background: var(--pharma-mist);
}

html.dark .pharma-pill-btn--outline:hover,
[data-theme="dark"] .pharma-pill-btn--outline:hover {
    background: var(--slate-800);
}

@media print {
    @page {
        margin: 12mm;
    }

    .no-print {
        display: none !important;
    }

    .pharma-shell {
        max-width: 100%;
        padding: 0;
    }

    .pharma-header {
        margin-bottom: 1rem;
    }

    /* The radial hotspot diagram is a large interactive aid meant for
       screen use; on paper only the cover image and its labels matter,
       so it's shrunk down instead of eating half a page. */
    .pharma-diagram-card {
        padding: 1rem;
        margin-bottom: 1rem;
    }

    .pharma-stage {
        max-width: 220px;
    }

    .pharma-diagram-caption {
        display: none;
    }

    .pharma-accordion {
        gap: 0.4rem;
    }

    .pharma-acc-item {
        break-inside: avoid;
        border: 1px solid var(--slate-200, #e2e8f0);
    }

    /* Print the full fact sheet regardless of what's expanded on screen. */
    .pharma-acc-body-wrap {
        display: block !important;
    }

    .pharma-acc-body-inner {
        overflow: visible !important;
    }

    .pharma-acc-body {
        padding: 0.75rem 1rem;
    }

    .pharma-acc-chevron {
        display: none;
    }

    .pharma-prose,
    .pharma-body-text {
        font-size: 0.8rem;
        line-height: 1.5;
    }
}

/* ---------------- Diagram card ---------------- */
.pharma-diagram-card {
    border-radius: 1.5rem;
    background: linear-gradient(to bottom right, var(--pharma-mist), #fff, #fff);
    box-shadow: 0 0 0 1px var(--slate-100);
    padding: 2rem 1rem;
    margin-bottom: 2.5rem;
}

html.dark .pharma-diagram-card,
[data-theme="dark"] .pharma-diagram-card {
    background: linear-gradient(to bottom right, var(--slate-900), var(--slate-900), var(--slate-950));
    box-shadow: 0 0 0 1px var(--slate-800);
}

@media (min-width: 640px) {
    .pharma-diagram-card {
        padding: 2.5rem 1.5rem;
    }
}

.pharma-stage-wrap {
    display: flex;
    justify-content: center;
}

.pharma-stage {
    position: relative;
    width: 100%;
    max-width: 28rem;
    aspect-ratio: 1 / 1;
}

@media (min-width: 640px) {
    .pharma-stage {
        max-width: 32rem;
    }
}

.pharma-ring {
    position: absolute;
    border-radius: 9999px;
    border: 1px solid var(--pharma-teal);
    pointer-events: none;
}

.pharma-ring--outer {
    inset: 6%;
    border-color: rgba(44, 100, 120, 0.15);
}

.pharma-ring--inner {
    inset: 16%;
    border-color: rgba(44, 100, 120, 0.10);
}

.pharma-cover-box {
    position: absolute;
    border-radius: 1rem;
    box-shadow: var(--shadow-2xl), 0 0 0 1px rgb(0 0 0 / 0.05);
    background: #fff;
    overflow: hidden;
}

html.dark .pharma-cover-box,
[data-theme="dark"] .pharma-cover-box {
    background: var(--slate-800);
}

.pharma-cover-box img {
    width: 100%;
    height: 100%;
    object-fit: cover;
}

.pharma-connector-svg {
    position: absolute;
    inset: 0;
    width: 100%;
    height: 100%;
    pointer-events: none;
}

.pharma-pin {
    position: absolute;
    width: 6px;
    height: 6px;
    border-radius: 9999px;
    box-shadow: 0 0 0 1px #fff, var(--shadow-sm);
    transform: translate(-50%, -50%);
}

html.dark .pharma-pin,
[data-theme="dark"] .pharma-pin {
    box-shadow: 0 0 0 1px var(--slate-900), var(--shadow-sm);
}

.pharma-badge {
    position: absolute;
    width: 10rem;
    text-decoration: none;
    display: block;
}

@media (min-width: 640px) {
    .pharma-badge {
        width: 13rem;
    }
}

.pharma-badge-row {
    display: flex;
    flex-direction: row;
    align-items: center;
    gap: 0.5rem;
}

.pharma-badge-row--reverse {
    flex-direction: row-reverse;
}

.pharma-badge-icon {
    width: 36px;
    height: 36px;
    border-radius: 9999px;
    background: #fff;
    display: flex;
    align-items: center;
    justify-content: center;
    flex-shrink: 0;
    transition: transform 0.2s ease-in-out;
}

html.dark .pharma-badge-icon,
[data-theme="dark"] .pharma-badge-icon {
    background: var(--slate-900);
}

.pharma-badge:hover .pharma-badge-icon {
    transform: scale(1.1);
}

.pharma-badge-icon svg {
    width: 16px;
    height: 16px;
    stroke-width: 2;
    fill: none;
}

@media (min-width: 640px) {
    .pharma-badge-icon {
        width: 44px;
        height: 44px;
    }

    .pharma-badge-icon svg {
        width: 20px;
        height: 20px;
    }
}

.pharma-badge-label {
    border-radius: 9999px;
    padding: 0.25rem 0.75rem;
    color: #fff;
    font-weight: 700;
    text-transform: uppercase;
    letter-spacing: 0.025em;
    font-size: 10px;
    line-height: 1.3;
    box-shadow: var(--shadow-sm);
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
    max-width: 100%;
}

@media (min-width: 640px) {
    .pharma-badge-label {
        font-size: 12px;
    }
}

.pharma-badge-subtitles {
    margin-top: 0.375rem;
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 0.125rem;
}

.pharma-badge-subtitle {
    display: flex;
    flex-direction: row;
    align-items: center;
    gap: 0.25rem;
    max-width: 100%;
}

.pharma-badge-subtitle-dot {
    width: 4px;
    height: 4px;
    border-radius: 9999px;
    background: var(--slate-700);
    flex-shrink: 0;
}

html.dark .pharma-badge-subtitle-dot,
[data-theme="dark"] .pharma-badge-subtitle-dot {
    background: var(--slate-300, #cbd5e1);
}

.pharma-badge-subtitle-text {
    font-size: 9px;
    line-height: 1.3;
    color: var(--slate-700);
    white-space: nowrap;
    overflow: hidden;
    text-overflow: ellipsis;
}

@media (min-width: 640px) {
    .pharma-badge-subtitle-text {
        font-size: 10px;
    }
}

html.dark .pharma-badge-subtitle-text,
[data-theme="dark"] .pharma-badge-subtitle-text {
    color: var(--slate-300, #cbd5e1);
}

.pharma-diagram-caption {
    text-align: center;
    font-size: 0.75rem;
    line-height: 1rem;
    color: var(--slate-400);
    margin-top: 0.75rem;
}

html.dark .pharma-diagram-caption,
[data-theme="dark"] .pharma-diagram-caption {
    color: var(--slate-500);
}

/* ---------------- Accordion ---------------- */
.pharma-accordion {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.pharma-acc-item {
    border-radius: 1rem;
    border: 1px solid var(--slate-100);
    background: #fff;
    overflow: hidden;
}

html.dark .pharma-acc-item,
[data-theme="dark"] .pharma-acc-item {
    border-color: var(--slate-800);
    background: var(--slate-900);
}

.pharma-acc-header {
    width: 100%;
    display: flex;
    flex-direction: row;
    align-items: center;
    gap: 0.75rem;
    padding: 1rem 1.25rem;
    text-align: start;
    background: rgba(167, 188, 197, 0.4);
    border: none;
    cursor: pointer;
    transition: background-color 0.2s ease-in-out;
    font: inherit;
}

.pharma-acc-header:hover {
    background: rgba(167, 188, 197, 0.6);
}

html.dark .pharma-acc-header,
[data-theme="dark"] .pharma-acc-header {
    background: var(--slate-800);
}

html.dark .pharma-acc-header:hover,
[data-theme="dark"] .pharma-acc-header:hover {
    background: var(--slate-700);
}

.pharma-acc-badge {
    width: 40px;
    height: 40px;
    border-radius: 9999px;
    flex-shrink: 0;
    display: flex;
    align-items: center;
    justify-content: center;
}

.pharma-acc-badge--number {
    color: #fff;
    font-weight: 700;
    box-shadow: var(--shadow-sm);
}

.pharma-acc-badge--icon svg {
    width: 20px;
    height: 20px;
    stroke-width: 1.75;
    fill: none;
}

.pharma-acc-title {
    flex: 1 1 auto;
    font-weight: 600;
    color: var(--slate-800);
    min-width: 0;
}

html.dark .pharma-acc-title,
[data-theme="dark"] .pharma-acc-title {
    color: var(--slate-100);
}

.pharma-acc-chevron {
    width: 20px;
    height: 20px;
    stroke-width: 2;
    fill: none;
    color: var(--slate-400);
    flex-shrink: 0;
    transition: transform 0.3s ease-in-out;
}

[dir="rtl"] .pharma-acc-chevron {
    transform: rotate(180deg);
}

.pharma-acc-item.is-open .pharma-acc-chevron {
    transform: rotate(180deg);
}

[dir="rtl"] .pharma-acc-item.is-open .pharma-acc-chevron {
    transform: rotate(360deg);
}

.pharma-acc-body-wrap {
    display: grid;
    grid-template-rows: 0fr;
    transition: grid-template-rows 0.3s ease-in-out;
}

.pharma-acc-item.is-open .pharma-acc-body-wrap {
    grid-template-rows: 1fr;
}

.pharma-acc-body-inner {
    overflow: hidden;
}

.pharma-acc-body {
    border-top: 1px solid var(--slate-100);
    background: #fff;
    padding: 1.25rem;
}

html.dark .pharma-acc-body,
[data-theme="dark"] .pharma-acc-body {
    border-color: var(--slate-800);
    background: var(--slate-900);
}

.pharma-acc-body--indent {
    padding-inline-start: 4.25rem;
}

/* Prose (description / note HTML) */
.pharma-prose {
    font-size: 0.875rem;
    line-height: 1.6;
    color: var(--slate-600);
}

html.dark .pharma-prose,
[data-theme="dark"] .pharma-prose {
    color: var(--slate-300, #cbd5e1);
}

.pharma-prose p {
    margin: 0 0 0.75rem;
}

.pharma-prose p:last-child {
    margin-bottom: 0;
}

.pharma-prose pre,
.pharma-prose code {
    direction: ltr;
    unicode-bidi: isolate;
    text-align: start;
    font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
    background: var(--slate-50);
    color: var(--slate-700);
    border: 1px solid var(--slate-100);
    border-radius: 0.5rem;
}

html.dark .pharma-prose pre,
html.dark .pharma-prose code,
[data-theme="dark"] .pharma-prose pre,
[data-theme="dark"] .pharma-prose code {
    background: var(--slate-800);
    color: var(--slate-100);
    border-color: var(--slate-700, #334155);
}

.pharma-prose pre {
    padding: 1rem;
    overflow-x: auto;
    white-space: pre-wrap;
    word-break: break-word;
    margin: 0 0 0.75rem;
}

.pharma-prose code {
    padding: 0.15rem 0.4rem;
    font-size: 0.85em;
}

.pharma-prose a {
    color: var(--pharma-teal);
}

/* Body row pattern: text + optional image */
.pharma-body-row {
    display: flex;
    flex-direction: row;
    gap: 1rem;
    align-items: flex-start;
}

.pharma-body-text {
    flex: 1 1 auto;
    white-space: pre-line;
    font-size: 0.875rem;
    line-height: 1.6;
    color: var(--slate-600);
    min-width: 0;
}

html.dark .pharma-body-text,
[data-theme="dark"] .pharma-body-text {
    color: var(--slate-300, #cbd5e1);
}

.pharma-body-img {
    width: 128px;
    height: 128px;
    object-fit: cover;
    border-radius: 1rem;
    border: 1px solid var(--slate-100);
    box-shadow: var(--shadow-sm);
    flex-shrink: 0;
}

html.dark .pharma-body-img,
[data-theme="dark"] .pharma-body-img {
    border-color: var(--slate-700);
}

@media (min-width: 640px) {
    .pharma-body-img {
        width: 160px;
        height: 160px;
    }
}

/* Nested "Image Parts" list */
.pharma-nested-list {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.pharma-point-anchor {
    scroll-margin-top: 6rem;
}

.pharma-nested-body-list {
    margin: 0;
    padding-inline-start: 1.25rem;
    list-style: disc;
    font-size: 0.875rem;
    line-height: 1.6;
    color: var(--slate-600);
}

html.dark .pharma-nested-body-list,
[data-theme="dark"] .pharma-nested-body-list {
    color: var(--slate-300, #cbd5e1);
}

.pharma-nested-empty {
    font-size: 0.875rem;
    color: var(--slate-400);
    font-style: italic;
}

/* Repeatable importance sections */
.pharma-importance-body {
    display: flex;
    flex-direction: column;
    gap: 1.25rem;
}

@media (min-width: 640px) {
    .pharma-importance-body {
        flex-direction: row;
    }
}

.pharma-importance-main {
    flex: 1 1 auto;
    display: flex;
    flex-direction: column;
    gap: 1rem;
    min-width: 0;
}

.pharma-sub-label {
    text-transform: uppercase;
    font-size: 0.75rem;
    font-weight: 700;
    letter-spacing: 0.025em;
    color: var(--pharma-teal);
    margin: 0 0 0.375rem;
}

.pharma-importance-trailing-img {
    width: 160px;
    height: 160px;
    object-fit: cover;
    border-radius: 1rem;
    border: 1px solid var(--slate-100);
    box-shadow: var(--shadow-sm);
    flex-shrink: 0;
}

html.dark .pharma-importance-trailing-img,
[data-theme="dark"] .pharma-importance-trailing-img {
    border-color: var(--slate-700);
}

/* Dark-mode toggle (local to this page) */
.pharma-theme-toggle {
    width: 36px;
    height: 36px;
    border-radius: 9999px;
    border: 1px solid var(--slate-200);
    background: #fff;
    color: var(--slate-600);
    display: inline-flex;
    align-items: center;
    justify-content: center;
    cursor: pointer;
    margin-inline-start: 0.5rem;
}

html.dark .pharma-theme-toggle,
[data-theme="dark"] .pharma-theme-toggle {
    background: var(--slate-800);
    border-color: var(--slate-700);
    color: var(--slate-100);
}

.pharma-theme-toggle svg {
    width: 16px;
    height: 16px;
}

.pharma-theme-toggle .icon-sun {
    display: none;
}

html.dark .pharma-theme-toggle .icon-moon,
[data-theme="dark"] .pharma-theme-toggle .icon-moon {
    display: none;
}

html.dark .pharma-theme-toggle .icon-sun,
[data-theme="dark"] .pharma-theme-toggle .icon-sun {
    display: block;
}

.pharma-topline {
    display: flex;
    align-items: center;
    justify-content: space-between;
}

.pharma-scope .gated-overlay-wrap {
    position: relative;
}

.pharma-scope .gated-overlay-wrap.is-locked .gated-overlay-content {
    filter: blur(6px);
    pointer-events: none;
    user-select: none;
    max-height: 720px;
    overflow: hidden;
}

.pharma-scope .gated-overlay-mask {
    position: absolute;
    inset: 0;
    z-index: 10;
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    text-align: center;
    padding: 40px 24px;
    background: rgba(255, 255, 255, 0.85);
}

html.dark .pharma-scope .gated-overlay-mask,
[data-theme="dark"] .pharma-scope .gated-overlay-mask {
    background: rgba(15, 23, 42, 0.85);
}

.pharma-scope .gated-overlay-lock {
    width: 76px;
    height: 76px;
    border-radius: 50%;
    background: #fff;
    box-shadow: var(--shadow-2xl);
    display: flex;
    align-items: center;
    justify-content: center;
    color: var(--pharma-teal);
    font-size: 30px;
    margin-bottom: 20px;
}

html.dark .pharma-scope .gated-overlay-lock,
[data-theme="dark"] .pharma-scope .gated-overlay-lock {
    background: var(--slate-800);
}

.pharma-scope .gated-overlay-mask h3 {
    color: var(--slate-800);
    margin-bottom: 8px;
}

html.dark .pharma-scope .gated-overlay-mask h3,
[data-theme="dark"] .pharma-scope .gated-overlay-mask h3 {
    color: var(--slate-100);
}

.pharma-scope .gated-overlay-mask p {
    color: var(--slate-600);
    margin-bottom: 24px;
    max-width: 420px;
}

.pharma-scope .gated-overlay-actions {
    display: flex;
    flex-wrap: wrap;
    gap: 12px;
    justify-content: center;
}

.pharma-scope .gated-overlay-actions a {
    display: inline-flex;
    align-items: center;
    gap: 8px;
    padding: 12px 24px;
    border-radius: 999px;
    font-weight: 600;
    text-decoration: none;
}

.pharma-scope .gated-overlay-actions a.theme-btn {
    background: var(--pharma-teal);
    color: #fff;
}

.pharma-scope .gated-overlay-actions a.style-2 {
    background: transparent;
    border: 1px solid var(--pharma-teal);
    color: var(--pharma-teal);
}